“The influence of wear particles on in vitro and in vivo cell response – A Comprehensive Review

“The influence of wear particles on in vitro and in vivo cell response – A Comprehensive Review from Six Degrees of Freedom - Orthopedic Implant Wear Testing

By: Six Degrees of Freedom - Orthopedic Implant Wear Testing   12-04-2010
Keywords: Implant, Orthopedic, Artificial Implant Testing

A comprehensive up to date literature review of 58 peer reviewed articles on the influence of wear particles on the in vivo and in vitro cell responses in the body. The article is a 62 page well laid out review consisting of approximately 15000 words.

This article describes the various cell reactions in the body to polymer, metal, ceramic and elastomer particles that accumulate adjacent to implanted devices. It is well known that the development of osteolysis and therefore implant failure is primarily a consequence of the accumulation of wear debris. This article highlights the following:

  • Details of specific cell reactions to wear debris in the body

  • Describes various wear mechanisms of biocompatible materials

  • Compares and contrasts these responses as a function of particle type

  • Discusses the critical particle size range that results in osteolysis

  • Described the cytotoxic effects of different particles 

Keywords: Artificial Implant Testing, Facet Joint Arthroplasty – A Review of the Biomechanics, Facet Joint Certification, FDA Certification, Implant, in vitro and in vivo cell response – A Comprehensive Literature Review, Orthopedic, Orthopedic Implant Testing, Review Articles - Facet Joint Replacement, Wear Debris Testing, Wear Particle Analysis,

Contact Six Degrees of Freedom - Orthopedic Implant Wear Testing

Email

Print this page

Share